هذه قصة السكين كاب لمن اراد ان يقرأها واسف انه ليس لدي وقت لاترجمها .
http://dermatology.cdlib.org/DOJvol3...als/smith.html
Skin Cap Spray is a non-pre******ion medication that appeared on the North American market in 1995. It contains zinc pyrithione and several other chemicals. Skin Cap was allowed to be sold without a pre******ion because the active ingredient was claimed to be zinc pyrithione, which was originally allowed for non-pre******ion sale in put-on wash-off products such as shampoos for the treatment of dandruff and seborrhoeic dermatitis. There is no published information on the safety of zinc pyrithione as a put-on, leave-on product.
Starting in 1995 in North America Skin Cap became very popular among psoriatics because it was often helpful where other treatments, including topical corticosteroids, had been ineffective. Dermatologists were very impressed with the results and with the apparent safety, and many dermatologists recommended Skin Cap spray to their patients, and some sold Skin Cap spray to their patients. Skin Cap spray was also sold by mail order, through 1-800 numbers, and at some pharmacy chains.
The story of Skin Cap unfolded for many dermatologists and for many patients on the internet, notably in the RxDerm-L mailing list for dermatologists, and on the alt.support.psoriasis newsgroup for psoriatics. Those who monitored these sources of information (and occasional misinformation and misplaced enthusiasm) were among the first to become aware of Skin Cap, and were also among the first to become aware of potential problems with Skin Cap.
Dermatologists noted that Skin Cap appeared to be a very potent broad spectrum anti-inflammatory, and reports of Skin Cap's effectiveness in the management of recalcitrant inflammatory diseases including discoid lupus, dermatomyositis, and lichen planus were posted on the Internet mailing list RxDerm-L.
Apart from occasional reports of skin irritation after exposure to Skin Cap, or explosive flares of psoriasis when Skin Cap was stopped, there were no reports of problems with Skin Cap.
In 1996 information started to circulate that some jurisdictions in Europe (notably Austria and Holland) had found corticosteroids (clobetasol propionate or triamcinolone) in Skin Cap, and had banned Skin Cap for this reason.
In July 1997 samples of Skin Cap spray sold in North America were found by several excellent laboratories, including the Mayo Clinic and Glaxo Inc. using "high performance liquid chromatography" to contain clobetasol propionate. This finding has been disputed by Cheminova Inc., the marketer of Skin Cap. Cheminova had denied that there are corticosteroids in Skin Cap, and Cheminova has asserted that when Skin Cap is analyzed using the MALDI-TOF mass spectrometer test it will show that Skin Cap contains a chemical which is confused with - but is not the same as - clobetasol propionate on high performance liquid chromatography.